Combination Therapy with Olmesartan and Amlodipine in the Treatment of Hypertension
نویسندگان
چکیده
BACKGROUND Combination therapy with antihypertensive agents utilises different mechanisms of action and may be responsible for a more effective decrease in blood pressure. OBJECTIVE To review the recently published trials on efficacy and safety of the combination therapy with olmesartan and amlodipine. RESULTS The double-blind American COACH (Combination of Olmesartan Medoxomil and Amlopdine Besylate in Controlling High Blood Pressure) study (2008) showed in 1,940 patients that after eight weeks of treatment the BP goals were most frequently achieved in the 'combination therapy group', with 56.3% (54.1-58.5%) and 54.0% (51.8-56.2%) of patients reaching adequate blood pressure of.
منابع مشابه
Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan – amlodipine combination
Although the awareness and control of hypertension has increased, only 37% of hypertensive patients in the US achieve the conservative goal of <140/90 mmHg. Achieving optimal blood pressure (BP) control is the most important single issue in the management of hypertension, and in most hypertensive patients, it is difficult or impossible to control BP with one drug. Blocking two or more BP regula...
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